CBD metabolism can be a complex subject because there are so many variables that affect the metabolism of CBD in our bodies. If you have been wondering “how is CBD metabolized?,” we are here to break it down for you.
What is CBD Metabolism?
Metabolism is your body’s conversion of chemical compounds through proteins called enzymes. Enzymes are proteins that are natural to your body and “catalyze” or speed up chemical reactions.
The majority of your body’s metabolism occurs in the gut wall, lungs, and blood plasma.
The most important enzymes to metabolism are a part of a group called “Cytochrome P450.”
There are two phases in metabolism – 1 and 2. In phase 1, your body goes through oxidation and loses electrons. After the completion of phase 1, substances are said to be “oxidized.”
In phase 2, your body makes contents more water soluble, so they can be expelled from your body. Contents become inactive during this phase. As substances begin to leave your body, they lose their pharmacological activity.
To sum up, substances enter your body at their peak chemical activity. As they go through phase 1 and 2, they pass through the liver’s enzymes and begin to break down. After the completion of phase 2, a substance is inactive and water soluble enough to leave your system.
How Is CBD Metabolized?
Now that you have more of an understanding of metabolism, we can move on to talk about the metabolism of Cannabidiol, or CBD.
As CBD begins to metabolize, it is converted into chemical compounds 7-OH-CBD and 6-OH-CBD in the liver.
As of now, not much is known about these two metabolites. However, there is a chemical called D2 (E) Valproate, which has anticonvulsant effects that might contribute to the anti-epileptic nature of CBD.
Cytochrome P450
As we mentioned, Cytochrome P450 is the group of enzymes that are important to metabolism function. With CBD, it seems to have an inhibitory effect on the metabolism of other chemicals. In other words, it seems to take up the metabolic bandwidth of Cytochrome P450 so other chemicals aren’t metabolized.
Something as simple as CBD Capsules could disrupt the metabolism of other substances.
Now, this effect won’t always be the same – it will vary for individuals and depends on the pairing of CBD to the Cytochrome P450 enzyme group.
Still, it is important to be aware of this effect so you can know how CBD interacts with other substances in your system. If you take medications, talk to your doctor before taking CBD.
How Is CBD Oil Metabolized?
CBD Oil is used sublingually (under the tongue) in order for it to be absorbed by the mucus membranes and go directly to the bloodstream.
How Quickly Is CBD Metabolized?
CBD metabolism varies depending on the CBD products you use and your size, sex, and more. Vaping CBD and using CBD Oil sublingually are metabolized faster than products like CBD Gummies and CBD Capsules that go through the digestive system. Read more about CBD gummies effects and how does CBD Oil make you feel.
How Is Topical CBD Metabolized?
Further research needs to be done to fully understand how CBD topicals are metabolized. These products are meant to treat a surface area on the body. At this time it does not appear that topical CBD is absorbed into the blood and, therefore, is not metabolized internally. CBD Pain Freeze provides comfort without metabolizing into your bloodstream.
How Is Sublingual CBD Metabolized?
Sublingual CBD or CBD Oil is metabolized in the bloodstream when it is absorbed through the mucus membranes.
How Is CBD Metabolized In The Body?
CBD is metabolized differently depending on the method of ingestion and other factors.
When CBD edibles are consumed, CBD must first go through the digestive system before reaching the bloodstream. This means that the bioavailability of edibles is lower than other forms of CBD. However, edibles allow for a longer-lasting effect.
CBD Oil, when taken correctly, is absorbed by the mucus membranes in the mouth and travels directly to the bloodstream.
Vaping CBD allows for quick absorption into the alveoli in the lungs which then push the CBD into your bloodstream. CBD Vaping offers fast results, but the results won’t last as long as other methods.
We hope we helped you grasp the in-depth concept of CBD Metabolism. CBD metabolism is an interesting subject because the method of CBD ingestion and your own body can affect the rate of metabolism, the way the CBD is metabolized and the bioavailability of the CBD in your body. Some of this information may help you determine the best way for you to take CBD, but it is important to start with small serving sizes no matter the method of CBD consumption. We also recommend talking to your doctor if you take medications that work with the Cytochrome P450 enzymes.
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Are there any specifics as to which other substances?